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Trifluoroacetic anhydride

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  • Chemical formula: C₄F₆O₃

  • Molecular weight: ~210.02 g/mol

  • Appearance: Colorless to pale yellow liquid

  • Odor: Pungent, corrosive

  • Boiling point: ~39–40 °C

  • Density: ~1.49 g/cm³ (20 °C)

  • Reactivity: Strong acylating agent; reacts violently with water

Key Applications

  • Powerful trifluoroacetylation reagent

  • Used in pharmaceutical and fine chemical synthesis

  • Activation of carboxylic acids and alcohols

  • Intermediate for fluorinated compounds

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